Interstate 405 (I-405) is the outer loop of Interstate 5 that runs from Lynnwood to Tukwila (and the airport), through Bothell.

There are tolls for the express lanes of I-405, with rates that vary by time of day and traffic levels. There are no toll booths. If the vehicle has a "Good to Go" sticker on the windshield, the toll is deducted from a prepaid account. Otherwise, transponders take a picture of the license plates, front and back, and mail the bill to the registered owner.

State Route 522 (WA-522) runs as Bothell Way from North Seattle to the west, and as a separated highway from Woodinville and I-405 to the east.

The Burke-Gilman Trail runs along the western rim of Lake Washington through Seattle and Lake Forest Park, then along the Sammamish River through Kenmore, Bothell, Woodinville, and Redmond. Despite the hilly surroundings, the track is flat as it used to be a railway line.

• 47.7547-122.2591 Kenmore Air Harbor, 6321 NE 175th St, Kenmore. A seaplane base at the northern end of Lake Washington. It is primarily used by regional seaplane airline Kenmore Air, serving areas all around Puget Sound and Canada. (updated Apr 2025)

Bothell Way (WA-522) is the main east-west artery, and really the only practical east-west through-road in the area. Before the floating bridges, it was the most direct way to get around Lake Washington, and the suburban roadside development still echoes its history as an old highway.

Main Street is the heart of downtown Bothell, a small walkable area around which flows towards the growing UW Bothell campus.

• Community Transit, ☏ +1 425-353-7433, toll-free: +1-800-562-1375. Operates local and regional public transit bus routes in Snohomish County, except only local routes in Everett. Communities within the county served by this operator's routes include Arlington, Edmonds, Everett, Lynnwood, Marysville, Mill Creek, Monroe, Mountlake Terrace, Mukilteo, Snohomish, and Stanwood from Bothell: (updated Jun 2023)

• Swift Green connects Seaway Transit to Canyon Park P&R, north of Botthell, via Airport Rd, 126th SW and Bothell-Everett Hwy. This replaces route 105.
• Route 106 connects UW Bothell and downtown Bothell to Mariner P&R
• Route 120 connects Canyon Park to Lynnwood Transit Center via Bothell
• Route 424 connects SR-522 and 132nd Ave NE stop in Woodinville (nearest to Bothell) with Snohomish via Monroe in one direction and downtown Seattle in the other. This route operates during weekday peak hours. Goes towards Seattle in the mornings and towards Snohomish during the evenings. Passengers transfer to 522 from SR-522 and 12nd Ave NE to get into Bothell.

• King County Metro, ☏ +1 206-553-3000. Operates bus, streetcar, and monorail routes in King County. Communities within the county served by this operator's routes include Auburn, Bellevue, Bothell, Burien, Federal Way, Issaquah, Kent, Kirkland, Mercer Island, North Bend, Redmond, Renton, SeaTac, Seattle, Shoreline, Tukwila, Vashon Island, White Center, and Woodinville. (updated Jun 2023)

• Route 230 Woodinville to Kirkland through Bothell, Brikyard and Juanita. Travels mainly on the west side of the I-405 corridor.
• Route 239 Bothell to Kirkland via Brickyard P&R and Totem Lake Transit Center. Travels mainly on 124th Ave NE east of the I-405 corridor.
• Route 372 goes around Lake Washington towards University Washington in the U-District through Lake City, Kenmore and Forest Park from UW Bothell/Cascadia College. It approaches UW on 25th Ave NE.

• Sound Transit, toll-free: +1-888-889-6368. Has regional public transit routes including Sounder trains, Link light rail, and express bus in King County (e.g. Bellevue, Federal Way, Kent, Renton, Seattle), Snohomish County (e.g. Everett, Lynnwood), and Pierce County (e.g. Puyallup, Tacoma). (updated Jun 2023)
  • Route 522 goes around Lake Washington towards the Roosevelt Station in Ravenna (north of Seattle) along Bothell-Lake City Wy (SR-522) through Lake City, Kenmore and Forest Park.
  • Route 535 Bellevue to Lynnwood via Totem Lake, Canyon Park, UW Bothell/Cascadia College and Bothell P&R on I-405 and Alderwood Pkwy in Lynnwood.